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 INTERMEDIATES UNDER DEVELOPMENT :-
 S.No.  API  INTERMIDIATES  CAS No
1  Apixaban  5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone  503615-03-0
2  Apixaban  Chloro[(4-methoxyphenyl)hydrazono]- acetic acid ethyl ester  27143-07-3
3  Apixaban          1H-Pyrazolo[3,4-c]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-1  -(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]- ,  methyl ester  1074365-84-6 
4  Bilastine         Methyl 2-(4-(2-chloroethyl) phenyl)-2-methylpropanoate  1181267-33-3 
5  Bilastine         1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole  hydrochloride  110963-63-8       
6  Bilastine         2-Ethoxyethyl 4-methyl benzenesulfonate  17178-11-9 
7  Bilastine         Methyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2 -yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate (N- 1 Intermediate)   1181267-38-8 
8  Bilastine         2-(2-(4-(2-(4-(1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1  -yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole (N-1  Intermediate)  202189-77-3 
9  Dapagliflozin  (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone  461432-22-4 
10  Dapagliflozin     5-Bromo-2-chloro-4’-ethoxydiphenylmethane  461432-23-5
11  Empagliflozin  (S)-(5-Bromo-2-chlorophenyl)(4-((tetrahydrofuran-3  -yl)oxy) phenyl)  methanone  915095-84-0
12  Empagliflozin     (S)-(5-Bromo-2-chlorophenyl)(4-((tetrahydrofuran-3-yl)oxy) phenyl)  methanone  915095-84-0
13  Losartan          2-n-Butyl-4-chloro-5-formylimidazole (BCFI)   83857-96-9
14  Mirabegron        2-(4-Nitrophenyl)ethylamine hydrochloride   29968-78-3
15  Mirabegron        (R)-2-[2-(4-Aminophenyl)ethylamino]-1-phenylethanol hydrochloride   521284-22-0 
16  Rebamipide        Diethyl 2-acetamidomalonate  1068-90-2 
17  Rebamipide        (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl) phenyl)morpholin-3  -one hydrochloride  898543-06-1 
18  Ticagrelor        4,6-Dichloro-2-(propylthio)-5-pyrimidinamine  145783-15-9   
19  Telmisartan        N-Methyl-1,2-benzenediamine dihydrochloride  25148-68-9 

 SPECIALITY KSM / ADVANCED INTERMEDIATES AVAILABLE INDIAN / IMPORTED :
 API  INTERMIDIATES  CAS No.
 Imatininb  CAS No: 152460-10-1
 CAS No: 106261-49-8		  MADE IN INDIA
 MADE IN INDIA
 Dasatininb  CAS No: 302964-24-5
 CAS No: 1780-26-3
 CAS No: 302964-08-5 (advanced intermediate)		  MADE IN INDIA
 Teneligliptin  CAS NO;  MADE IN INDIA
 Lulicanazole  CAS NO;  MADE IN INDIA
 Afatinib  3-Amino-4-hydroxybenzoic acid  1571-72-8
   (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-  yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide   439081-18-2 
 Alectinib  Ethynyltriisopropylsilane  89343-06-6
 Axitinib  3-Iodo-6-nitroindazole
 6-Nitroindazole
 AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-  yl)sulfanyl)benzamide  		  70315-70-7
 7597-18-4

 319460-85-0 
 Ceritinib  2,4,5-Trichloropyrimidine  5750-76-5
 Dasatinib  2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid
 N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl- 4 -  pyrimidinyl)amino]-5-thiazolecarboxamide
 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
 Ethyl 2-amino 5-thiazolecarboxylate
 Methyl 2-amino 5-thiazolecarboxylate
 2-amino-5-thiazolecarboxylic acid		  302964-02-9
 302964-08-5

 302964-24-5
 32955-21-8
 6633-61-0
 40283-46-3
 Ibrutinib  Bis(triphenylphosphine)palladium(II) chloride
 (S)-1-Boc-3-hydroxypiperidine
 3'-Bromoacetophenone
 4-Phenoxybenzoic acid
 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine		  13965-03-2
 143900-44-1
 2142-63-4
 2215-77-2
 330786-24-8
 Lapatinib  6-Iodoquinazolin-4-one
 N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2 -  furaldehyde
 2-Amino-5-iodobenzoic acid
 Sodium triacetoxyborohydride
 N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine		  16064-08-7
 231278-20-9
 231278-84-5

 5326-47-6
 56553-60-7
 231278-20-9
 Lenvatinib  Methyl 4-amino-2-methoxybenzoate
 4-Amino-2-chlorobenzonitrile
 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7 -  methoxyquinoline-6-carboxamide		  27492-84-8
 20925-27-3
 417716-92-8
 Neratinib  trans-4-Dimethylaminocrotonic acid hydrochloride  848133-35-7
 Nilotinib  3-(dimethylamino)-1-(3-pyridyl)-2-propen-1-one
 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester  mononitrate
 3-(4 methyl imidazole -1-yl)-5-trifluoromethyl phenyl amine
 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 		 55314-16-4
 641569-96-2

 641571-11-1
 641569-94-0
 Ponatinib   3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4 -  methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide  943319-70-8 
 Sunitinib  5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid
 N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-  carboxamide
 5-fluoro-1,3-dihydro-indol-2-one (5-fluoro Oxindole)
 1-(3-Dimethyl-aminopropyl-3-ethylcarbodiimide hydrochloride
 N,N-Diethylethylenediamine		  5442-91-1
 356068-86-5

 56341-41-4

 100-36-7
 Vandetanib  7-(Benzyloxy)-4-chloro-6-methoxy quinazoline
 3-Bromo-5-fluoroaniline
 tert-Butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1 -  carboxylate
 (1-Methylpiperidin-4-yl) methanol
  162364-72-9
 7087-65-2
 166815-96-9

 20691-89-8
 Ruxolitini  4-Chloropyrrolo[2,3-d]pyrimidine  3680-69-1
 Bortezomib  (R)-BoroLeu-(+)-Pinanediol-CF3COOH
 N-[(1S)-1-benzyl-2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-  dioxa-4-boratricyclo[6.1.1.0~2,6~]dec-4-yl]butyl}amino)-2-oxoethyl]-2-  pyrazinecarboxamide
 Alpha Pinanediol Leucine Boronate Trifluoroacetate		  179324-87-9
 205393-22-2
 Carfilzomib  (S)-2((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido) -  3-phenylpropanoic acid  868540-16-3
 Nintedanib  2-Chloro-N-methyl-N-(4-notrophenyl)acetamide  (Nintedanib Esylate)  2653-16-9
 Palbociclib  Tert-Butyl-4-(6-Amino-3-Pyridyl)Piperazine-1-Carboxylate  571188-59-5
 Pazopanib  Pazopanib HCL 
 Pazopanib base		  635702-64-6 
 444731-52-6 
 Pomalidomide  3-Nitropthalic Anhydride  641-70-3
 Sorafenib  4-Chloro-3-Trifluoromethylphenyl Isocyante
 N-Methyl-4-chloropyridine-2-carboxamide
 [4-(4-aminophenoxy-2-pyridyl)]-n-methylcarboxamide
 4-Chloro-2-pyridinecarboxylic acid methyl ester hydrochloride
 220000-87-3
 284462-37-9
 176977-85-8
 Sunitinib Malate  N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3 -  carboxamide
 N-[2-(Diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-Carboxamide
 2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
 4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
 5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-  pyrrole- 3-carboxylic acid
 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H- pyrrole-3 -  carboxamid
 5-Fluoro-2-oxindole		  590424-04-7

 590424-05-8
 86770-31-2
 5442-91-1
 356068-93-4
 
 356068-86-5
 
 56341-41-4
 Vemurafenib  5-Bromo-7-azaindole  183208-35-7
 ANTI DIABETIC INTERMEDIATES
 Canagliflozin  [2-(5-Bromo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene]
 [2-(5-Bromo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene]
 5-Bromo-2-methylbenzoic acid
 2-(4-Fluorophenyl)-5-(5-Iodo-2-methylbenzyl)Thiophene		  1030825-20-7
 1132832-75-7
 79669-49-1
 898566-17-1
 Repaglinide  N-Acetyl-L-Glutamic Acid
 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid		  1188-37-0
 99469-99-5
 Vildagliptin  (2S)-1(Chloroacetyl)-2-pyrrolidine carbonitrile
 1-Amino-3-Admantanol
 L-Prolinamide		  207557-35-5
 702-82-9
 7531-52-4
 Dapagliflozin  2-Chloro-5-Iodobenzoic acid
 2-Chloro-5-Bromobenzoic acid
 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
 (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
 5-bromo-2-chloro-4-ethoxydiphenylmethane
 2-Amino-5-Bromobenzoic acid
 2,3,4,6-tetra-O-acetyl-1-{4-chloro-3-[(4-ethyloxyphenyl)methyl]phenyl} -  1-deoxy-beta-D-glucopyranose		  19094-56-5
 21739-92-4
 32384-65-9
 461432-22-4
 461432-25-5
 5794-88-7

 461432-25-7
 Linagliptin  2-(9-Chloromethyl)4-methylquinazoline
 R-3-Boc-Amino Piperidine
 T-Butyl-Pyridin-3yl-Carbonate-11
 8-Bromo-7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
 1-[(4-Methylquinazolin-2-yl)methyl]3-methyl-7-(2-butyn-1-yl)-8 -  bromoxanthine
 8-Bromo-3-Methyl Xanthine		  109113-72-6
 309956-78-3
 42192-35-5
 666816-98-4

 853029-57-9
 93703-24-3
 Sotagliflozin  2-chloro-5-iodobenzoic acid  19094-56-5

 SPECIALITY KSM / ADVANCED INTERMEDIATES AVAILABLE INDIAN / IMPORTED :
 API  INTERMIDIATES  CAS No.
 Imatininb  CAS No: 152460-10-1
 CAS No: 106261-49-8		  MADE IN INDIA
 MADE IN INDIA
 Dasatininb  CAS No: 302964-24-5
 CAS No: 1780-26-3
 CAS No: 302964-08-5 (advanced intermediate)		  MADE IN INDIA
 Teneligliptin  CAS NO;  MADE IN INDIA
 Lulicanazole  CAS NO;  MADE IN INDIA
 Afatinib  3-Amino-4-hydroxybenzoic acid  1571-72-8
   (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-  yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide   439081-18-2 
 Alectinib  Ethynyltriisopropylsilane  89343-06-6
 Axitinib  3-Iodo-6-nitroindazole
 6-Nitroindazole
 AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-  yl)sulfanyl)benzamide  		  70315-70-7
 7597-18-4

 319460-85-0 
 Ceritinib  2,4,5-Trichloropyrimidine  5750-76-5
 Dasatinib  2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid
 N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl- 4 -  pyrimidinyl)amino]-5-thiazolecarboxamide
 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
 Ethyl 2-amino 5-thiazolecarboxylate
 Methyl 2-amino 5-thiazolecarboxylate
 2-amino-5-thiazolecarboxylic acid		  302964-02-9
 302964-08-5

 302964-24-5
 32955-21-8
 6633-61-0
 40283-46-3
 Ibrutinib  Bis(triphenylphosphine)palladium(II) chloride
 (S)-1-Boc-3-hydroxypiperidine
 3'-Bromoacetophenone
 4-Phenoxybenzoic acid
 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine		  13965-03-2
 143900-44-1
 2142-63-4
 2215-77-2
 330786-24-8
 Lapatinib  6-Iodoquinazolin-4-one
 N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
 5-[4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2 -  furaldehyde
 2-Amino-5-iodobenzoic acid
 Sodium triacetoxyborohydride
 N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine		  16064-08-7
 231278-20-9
 231278-84-5

 5326-47-6
 56553-60-7
 231278-20-9
 Lenvatinib  Methyl 4-amino-2-methoxybenzoate
 4-Amino-2-chlorobenzonitrile
 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7 -  methoxyquinoline-6-carboxamide		  27492-84-8
 20925-27-3
 417716-92-8
 Neratinib  trans-4-Dimethylaminocrotonic acid hydrochloride  848133-35-7
 Nilotinib  3-(dimethylamino)-1-(3-pyridyl)-2-propen-1-one
 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester  mononitrate
 3-(4 methyl imidazole -1-yl)-5-trifluoromethyl phenyl amine
 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 		 55314-16-4
 641569-96-2

 641571-11-1
 641569-94-0
 Ponatinib   3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4 -  methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide  943319-70-8 
 Sunitinib  5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid
 N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-  carboxamide
 5-fluoro-1,3-dihydro-indol-2-one (5-fluoro Oxindole)
 1-(3-Dimethyl-aminopropyl-3-ethylcarbodiimide hydrochloride
 N,N-Diethylethylenediamine		  5442-91-1
 356068-86-5

 56341-41-4

 100-36-7
 Vandetanib  7-(Benzyloxy)-4-chloro-6-methoxy quinazoline
 3-Bromo-5-fluoroaniline
 tert-Butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1 -  carboxylate
 (1-Methylpiperidin-4-yl) methanol
  162364-72-9
 7087-65-2
 166815-96-9

 20691-89-8
 Ruxolitini  4-Chloropyrrolo[2,3-d]pyrimidine  3680-69-1
 Bortezomib  (R)-BoroLeu-(+)-Pinanediol-CF3COOH
 N-[(1S)-1-benzyl-2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-  dioxa-4-boratricyclo[6.1.1.0~2,6~]dec-4-yl]butyl}amino)-2-oxoethyl]-2-  pyrazinecarboxamide
 Alpha Pinanediol Leucine Boronate Trifluoroacetate		  179324-87-9
 205393-22-2
 Carfilzomib  (S)-2((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido) -  3-phenylpropanoic acid  868540-16-3
 Nintedanib  2-Chloro-N-methyl-N-(4-notrophenyl)acetamide  (Nintedanib Esylate)  2653-16-9
 Palbociclib  Tert-Butyl-4-(6-Amino-3-Pyridyl)Piperazine-1-Carboxylate  571188-59-5
 Pazopanib  Pazopanib HCL 
 Pazopanib base		  635702-64-6 
 444731-52-6 
 Pomalidomide  3-Nitropthalic Anhydride  641-70-3
 Sorafenib  4-Chloro-3-Trifluoromethylphenyl Isocyante
 N-Methyl-4-chloropyridine-2-carboxamide
 [4-(4-aminophenoxy-2-pyridyl)]-n-methylcarboxamide
 4-Chloro-2-pyridinecarboxylic acid methyl ester hydrochloride
 220000-87-3
 284462-37-9
 176977-85-8
 Sunitinib Malate  N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3 -  carboxamide
 N-[2-(Diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-Carboxamide
 2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
 4-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid
 5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-  pyrrole- 3-carboxylic acid
 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H- pyrrole-3 -  carboxamid
 5-Fluoro-2-oxindole		  590424-04-7

 590424-05-8
 86770-31-2
 5442-91-1
 356068-93-4
 
 356068-86-5
 
 56341-41-4
 Vemurafenib  5-Bromo-7-azaindole  183208-35-7
 ANTI DIABETIC INTERMEDIATES
 Canagliflozin  [2-(5-Bromo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene]
 [2-(5-Bromo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene]
 5-Bromo-2-methylbenzoic acid
 2-(4-Fluorophenyl)-5-(5-Iodo-2-methylbenzyl)Thiophene		  1030825-20-7
 1132832-75-7
 79669-49-1
 898566-17-1
 Repaglinide  N-Acetyl-L-Glutamic Acid
 3-Ethoxy-4-ethoxycarbonyl phenylacetic acid		  1188-37-0
 99469-99-5
 Vildagliptin  (2S)-1(Chloroacetyl)-2-pyrrolidine carbonitrile
 1-Amino-3-Admantanol
 L-Prolinamide		  207557-35-5
 702-82-9
 7531-52-4
 Dapagliflozin  2-Chloro-5-Iodobenzoic acid
 2-Chloro-5-Bromobenzoic acid
 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
 (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
 5-bromo-2-chloro-4-ethoxydiphenylmethane
 2-Amino-5-Bromobenzoic acid
 2,3,4,6-tetra-O-acetyl-1-{4-chloro-3-[(4-ethyloxyphenyl)methyl]phenyl} -  1-deoxy-beta-D-glucopyranose		  19094-56-5
 21739-92-4
 32384-65-9
 461432-22-4
 461432-25-5
 5794-88-7

 461432-25-7
 Linagliptin  2-(9-Chloromethyl)4-methylquinazoline
 R-3-Boc-Amino Piperidine
 T-Butyl-Pyridin-3yl-Carbonate-11
 8-Bromo-7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione
 1-[(4-Methylquinazolin-2-yl)methyl]3-methyl-7-(2-butyn-1-yl)-8 -  bromoxanthine
 8-Bromo-3-Methyl Xanthine		  109113-72-6
 309956-78-3
 42192-35-5
 666816-98-4

 853029-57-9
 93703-24-3
 Sotagliflozin  2-chloro-5-iodobenzoic acid  19094-56-5

 IMPORTANT NOTE :-
 Homepage Products are Manufactured Products.
 Other Pages are Products Procured on Demand / Traded .


- DR. Madhukar Pharmaceuticals